Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS.
Identifieur interne : 004810 ( Main/Exploration ); précédent : 004809; suivant : 004811Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS.
Auteurs : Mei-Yun Zhang [États-Unis] ; Vidita Choudhry ; Xiaodong Xiao ; Dimiter S. DimitrovSource :
- Current opinion in molecular therapeutics [ 1464-8431 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (immunologie), Anticorps monoclonaux (usage thérapeutique), Humains, Immunoglobulines (génétique), Immunoglobulines (immunologie), Protéines virales (immunologie), Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Virus du SRAS (immunologie).
- MESH :
- génétique : Immunoglobulines.
- immunologie : Anticorps monoclonaux, Immunoglobulines, Protéines virales, Syndrome respiratoire aigu sévère, Virus du SRAS.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Anticorps monoclonaux.
- Animaux, Humains, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (therapeutic use), Humans, Immunoglobulins (genetics), Immunoglobulins (immunology), Mice, Mice, Transgenic, SARS Virus (immunology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology), Viral Proteins (immunology).
- MESH :
- chemical , genetics : Immunoglobulins.
- chemical , immunology : Antibodies, Monoclonal, Immunoglobulins, Viral Proteins.
- chemical , therapeutic use : Antibodies, Monoclonal.
- drug therapy : Severe Acute Respiratory Syndrome.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Animals, Humans, Mice, Mice, Transgenic.
Abstract
Polyclonal antibodies have a century-old history of being effective against some viruses and, recently, monoclonal antibodies (mAbs) have also shown some clinical success. Human mAbs to the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein have been developed by several research groups at an amazing pace. These antibodies potently neutralize infectious virus in tissue cultures and animal models, and, alone or in combination with vaccines and other drugs, may have potential for the prevention and treatment of SARS.
PubMed: 15844623
Affiliations:
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Le document en format XML
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Dimitrov</name></author></analytic><series><title level="j">Current opinion in molecular therapeutics</title><idno type="ISSN">1464-8431</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Humans</term><term>Immunoglobulins (genetics)</term><term>Immunoglobulins (immunology)</term><term>Mice</term><term>Mice, Transgenic</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (immunologie)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Humains</term><term>Immunoglobulines (génétique)</term><term>Immunoglobulines (immunologie)</term><term>Protéines virales (immunologie)</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunoglobulins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Immunoglobulins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Immunoglobulines</term><term>Protéines virales</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyclonal antibodies have a century-old history of being effective against some viruses and, recently, monoclonal antibodies (mAbs) have also shown some clinical success. Human mAbs to the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein have been developed by several research groups at an amazing pace. These antibodies potently neutralize infectious virus in tissue cultures and animal models, and, alone or in combination with vaccines and other drugs, may have potential for the prevention and treatment of SARS.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Choudhry, Vidita" sort="Choudhry, Vidita" uniqKey="Choudhry V" first="Vidita" last="Choudhry">Vidita Choudhry</name><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name><name sortKey="Xiao, Xiaodong" sort="Xiao, Xiaodong" uniqKey="Xiao X" first="Xiaodong" last="Xiao">Xiaodong Xiao</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Zhang, Mei Yun" sort="Zhang, Mei Yun" uniqKey="Zhang M" first="Mei-Yun" last="Zhang">Mei-Yun Zhang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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